Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019)
By Huang, Young, Skaper, Chene, Moviglia et al. Published in the Journal of Orthopaedic Translation. Volume 20, January 2020, Pages 14-24
Read more “Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019)”
Ozone therapy with local cellular immune modulation and disc progenitor cell implant is safe, effective and efficient
Ozone therapy with local cellular immune modulation and disc progenitor cell implant is safe, effective and efficient
Read more “Ozone therapy with local cellular immune modulation and disc progenitor cell implant is safe, effective and efficient”
Local immunomodulation and muscle progenitor cells induce recovery in atrophied muscles in spinal cord injury patients
The results presented here suggest that the combination of immune and regenerative cell therapy may play an important therapeutic role in clinical and histological recovery of chronic muscular atrophy. Read more “Local immunomodulation and muscle progenitor cells induce recovery in atrophied muscles in spinal cord injury patients”
Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)
The IANR and the Chinese Association of Neurorestoratology (CANR) collaborated to propose the current version “Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)”. Read more “Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)”
The Basis for a Rational and Integrated Immunotherapy for Advanced Breast Cancer
Dr. Gustavo A. Moviglia Ph.D thesis focused on presenting the rational basis for the use of immunotherapies (mono-immunotherapies, poly-immunotherapies or combined therapies) for the treatment of Advanced Breast Cancer. Read more “The Basis for a Rational and Integrated Immunotherapy for Advanced Breast Cancer”
Case report on the clinical results of a combined cellular therapy for chronic spinal cord injured patients
Objectives: With the intention to ameliorate the clinical condition of patients with chronic spinal cord injury (SCI), a program that combines three cell therapies and an appropriate neurorehabilitation program were used to recreate and enhance the natural conditions of SCI repair. Read more “Case report on the clinical results of a combined cellular therapy for chronic spinal cord injured patients”
Ética y normas internacionales para aceptar como «de uso corriente» una terapia innovadora
En este trabajo se reseñan las normas internacionales para aceptar como «de uso corriente» una terapia innovadora abordándose las cuestiones éticas implicadas en la misma. Read more “Ética y normas internacionales para aceptar como «de uso corriente» una terapia innovadora”
Immunomodulation of the Injury/Repair response of the CNS resident innate immune system as therapeutic approach for Amyotrophic Lateral Sclerosis
Abstract
Despite the metabolic dysfunctions found in Amyotrophic Lateral Sclerosis (ALS) motoneurons, the uncontrolled Injury/Repair Microglia function seems to be the main responsible for the fast and fatal disease progression. Read more “Immunomodulation of the Injury/Repair response of the CNS resident innate immune system as therapeutic approach for Amyotrophic Lateral Sclerosis”
Feasibility, Safety, and Preliminary Proof of Principles of Autologous Neural Stem Cell Treatment Combined With T-Cell Vaccination for ALS Patients
Uncontrolled activation of the innate immune system promotes the deterioration of neurons in different neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). T-cell vaccination (TCV) was developed by Irun Cohen and coworkers at the Weizmann Institute of Science (Israel) during the late 1970s and has been demonstrated to be an effective treatment for human autoimmune diseases and a regulator of macrophage activation in animal models.
Consensus of Clinical Neurorestorative Progress in Patients With Complete Chronic Spinal Cord Injury
Currently, there is a lack of effective therapeutic methods to restore neurological function for chronic complete spinal cord injury (SCI) by conventional treatment. Neurorestorative strategies with positive preclinical results have been translated to the clinic, and some patients have gotten benefits and their quality of life has improved. Read more “Consensus of Clinical Neurorestorative Progress in Patients With Complete Chronic Spinal Cord Injury”
Preliminary report on tumor stem cell/B cell hybridoma vaccine for recurrent glioblastoma multiforme
BACKGROUND: Glioblastoma multiforme (GBM), the most aggressive glioma, presents with a rapid evolution and relapse within the first year, which is attributed to the persistence of tumor stem cells (TSC) and the escape of immune surveillance. Mixed leukocyte culture (MLC) cytoimplant has been shown to function as a power- ful intratumor pro-inflammatory cytokine pump. Tumor B-cell hybridoma (TBH) vaccines have been shown to function as antigen-presenting cells. We evaluated the toxicity and efficiency of each treatment alone and in combination.
Autoreactive T cells induce in vitro BM mesenchymal stem cell transdifferentiation to neural stem cells
Background
The degree of post-injury inflammation of the damaged area of a spinal cord is the main difference between the natural successful repair in inferior vertebrates and failure in superior vertebrates. The treatment of rats with anti-myelin lymphocytes after experimental spinal cord injury induces their functional recovery. On the other hand, mesenchymal stem cells (MSC) from adult BM implanted in injured areas recover the morphology and function of spinal cord in mammals. The purpose of this study was to determine whether there is a direct relationship between anti-nervous tissue T cells and MSC reparatory properties. Read more “Autoreactive T cells induce in vitro BM mesenchymal stem cell transdifferentiation to neural stem cells”
Combined protocol of cell therapy for chronic spinal cord injury. Report on the electrical and functional recovery of two patients
Background
This is a preliminary report on successful results obtained during treatment of two patients with chronic spinal cord injury. The therapeutic approach was based on the generation of controlled inflammatory activity at the injury site that induced a microenviron- ment for the subsequent administration of autologous, BM-driven transdifferentiated neural stem cells (NSC). Read more “Combined protocol of cell therapy for chronic spinal cord injury. Report on the electrical and functional recovery of two patients”
In vitro Differentiation of Adult Adipose Mesenchymal Stem Cells into Retinal Progenitor Cells
Abstract
Introduction: It has been previously shown that adult mes- enchymal stem cells (MSCs) differentiate into neural progen- itor cells (NPCs) and that the differentiation process was completed in 24–48 h. In this previous study, MSCs from a bone marrow or fat source were co-incubated with homolo- gous autoaggressive cells (ECs) against nerve tissue, and these NPCs were successfully used in human regenerative therapeutic approaches. Read more “In vitro Differentiation of Adult Adipose Mesenchymal Stem Cells into Retinal Progenitor Cells”